Growth differentiation factor-15 (GDF-15) is a member of the transforming growth factor-β (TGF-β) superfamily and is involved in physiological and pathological processes such as tissue development, inflammation, tumors, and trauma, and is involved in the occurrence of various tumors And development. This article reviews the research progress on the structure of GDF-15, its relationship with tumorigenesis and development, and its expression regulation.
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