The research of nano-biomedicine is expected to play an important role in the diagnosis and treatment of major human diseases in the future, and it is currently a hot and frontier field of international research. Among them, mesoporous nano-biomaterials are currently the focus of international nanobiomedical research due to their adjustable nanoscale pore size, high specific surface area and pore volume, abundant chemical functional groups, and good biocompatibility and degradability .
The mesoporous and low-dimensional nanomaterials research group led by Shi Jianlin, a researcher at the Shanghai Institute of Ceramics, Chinese Academy of Sciences, is one of the earliest international research groups to carry out related research. Recently, the research group has made a series of important research progress in the design, preparation and application of multifunctional mesoporous nano-biomaterials.
First, in order to improve the drug coating ability of mesoporous nano-biomaterials, a novel selective etching method based on structural differences was proposed, and highly dispersed single-sized mesoporous silica hollow nanoparticles (ACS Nano, 2010, 4, 529); further by adjusting the etching time, the size of the mesopores on the wall can be effectively adjusted, making it possible to coat and transport biological macromolecules and nanoparticles (Small, 2011, 7, 2935); In order to provide the carrier with multi-functional characteristics on the basis of improving the drug coating ability, functional nanoparticles were introduced into the cavity of mesoporous silica nanoparticles to give them the function of clinical molecular imaging (ACS Nano, 2010, 4 , 6001); by adopting a novel layer-by-layer self-assembly method, a multifunctional nano-drug carrier integrating fluorescence / magnetic resonance dual-mode imaging and drug delivery functions is obtained (Adv. Funct. Mater., 2011, 21, 270); by adopting a method of in-situ decomposition and reduction, a multifunctional nano drug delivery system with a hollow magnetic core and a mesoporous double wall was successfully prepared (Adv. Funct. Mater., 2011, 21, 1850); Enter One-step assembly of gold nanorods on a multifunctional carrier yields a multifunctional mesoporous nanopharmaceutical carrier with synergistic treatment capabilities of heat and chemotherapy (Biomaterials, 2012, 33, 989); by using mesoporous channels to disperse the paramagnetic center of manganese , A new non-toxic, high-performance manganese-based MRI imaging contrast agent (Biomaterials, 2012, 33, 2388).
In terms of drug synergistic treatment, the research group used a combination of in situ surfactants and chemotherapeutic drugs to obtain a mesoporous nano drug carrier with drug synergistic treatment. The drug delivery system not only has nearly ideal pH-responsive drug release characteristics At the same time, it can effectively inhibit the multidrug resistance of drug-resistant cells (Biomaterials, 2011, 32, 7711; J. Mater. Chem., 2011, 21, 15190). A new inorganic "microemulsion" and inorganic "liposomes" based on mesoporous hollow nanomaterials were proposed by simultaneously coating the mesoporous / hydrophobic anti-cancer drugs in mesoporous nanocarriers The concept of "" (Adv. Funct. Mater., 2012, DOI: 10.1002 / adfm.201102052); In addition, the research group has also made research progress in the field of fluorescence imaging based on mesoporous nano-biomaterials, and successfully prepared a skeleton with fluorescence. Porous silicon oxide nanoparticles (Chemical Communications, 2011, 47, 7947).
Recently, the research team has worked closely with Chongqing Medical University, the Second Affiliated Hospital of Chongqing Medical University, Chongqing Haifu Company and other units to make important progress in the application of mesoporous nano-biomaterials in the field of non-invasive surgical treatment. High Intensity Focused Ultrasound (HIFU) has been widely used in clinic as an efficient, economical, non-invasive non-invasive treatment mode. However, how to effectively guide focused ultrasound to target the energy deposition of diseased tissues in the body and effectively improve the effect of HIFU treatment is a technical problem to be solved urgently. In addition to relying on costly equipment upgrades, the simple and easy nanobiotechnology provides a new way to solve this problem. The research group coated and transported temperature-sensitive fluorocarbon compounds with meso-porous silica hollow nanoparticles with a huge cavity structure for HIFU synergistic treatment (Adv. Mater., 2012, 24,785); further, through Design and prepare a mesoporous hollow nanoparticle with MRI navigation function, and coat and transmit temperature-sensitive fluorocarbon molecules through a huge cavity structure to achieve HIFU treatment with MRI imaging and MRI precise navigation positioning function and efficient enhancement The dual function of the effect.
Related research results were published in the internationally renowned academic journal "German Applied Chemistry" (Angew. Chem. Int. Ed., 2011, 50, 12505-12509).
The above research results were supported by the National Ministry of Science and Technology 973 Program, 863 Program, National Natural Science Foundation of China, Shanghai Venus Tracking Program, Shanghai Nano Special Project, and Shanghai Institute of Ceramics Graduate Incubation Program of the Chinese Academy of Sciences.
Picture in "Advanced Materials" magazine
Picture title in the "German Applied Chemistry" magazine
Plush Dog Toy,Dog Plush Toy,Squeaker Rope Tug Dog Toys,Plush Dog Toys
Dongguan King Pet Toys Co.,Ltd , https://www.kingpettoys.com