At present, British scientists have observed that death spreads like a wave in the body of the worm, and a mysterious blue fluorescence travels between the cells until the worm completely dies.
Researchers from the Wellcome Foundation and the Biotechnology and Biological Sciences Research Council (BBsrc) compared blue light through the worm's body to the death. People's death may eventually make people live longer.
When an individual cell dies, it initiates a chemical chain reaction, leading to the decomposition of cellular components and accumulated molecular debris. Scientists have fully understood this cell-level molecular mechanism before, but we rarely know how death spreads at the end of an organism's life.
Researchers can easily observe under the microscope how the blue fluorescent wave passes through the worm's internal organs, and the death is gradually approaching. It was revealed that this fluorescence is produced by a cell death pathway called "cell necrosis", which relies on calcium to transmit signals through the microbial body.
Professor David Gems of the Institute of Health and Aging, University College London, UK, was responsible for the study. He said: "We discovered a self-destructive chemical pathway that spreads cell death in worms. During our observation, we discovered The blue fluorescence passes through the entire body. It is like a blue death, spreading and spreading in the microorganisms until the end of life. We found that when blocking this path, we can delay death, but we cannot slow the death phenomenon caused by ageing.
This mechanism is similar to the activity of mammals, confirming that worms can be used as a useful model to understand human cell death. The source of this blue fluorescence was once thought to be a substance called lipofuscin, which emits similar colored light and is closely related to aging because it accumulates more and more molecular damage.
However, scientists currently believe that another molecule, anthranilic acid, is the source of blue light. The study shows that lipofuscin has nothing to do with the mysterious blue light. Professor James said that this research implies that aging is only the result of the accumulation of molecular damage. We need to focus on biological events in the process of aging and death, which helps us understand how to interrupt this process.
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