China Education Equipment Purchasing Network News: According to BioCommunications, the Institute of Molecular Medicine (IMM) of Peking University, Massachusetts General Hospital of Harvard Medical School in the United States and Roche Pharmaceutical Company in Switzerland have joined forces in "Circulation" (the famous American medical journal "Circulation") , Sponsored by the American Heart Association) published a research paper online, the title of the paper is "Rhesus macaques develop metabolic syndrome with reversible vascular dysfunction responsive to pioglitazone."
It is reported that the corresponding author of the article is Professor Cheng Heping of the Institute of Molecular Medicine of Peking University. Since 2007, he has served as the chief scientist and obtained the 973 project of the Ministry of Science and Technology "Research on the major foundation and disease mechanism of the heart". Professor Cheng Heping has published nearly 100 papers so far, 9 of which have been published in Science, Nature and Cell.
According to the news, the latest article published in "Circulation" is a large-scale cooperation between researchers from Peking University Institute of Molecular Medicine (IMM) and Harvard Medical School Massachusetts General Hospital and Swiss Roche Pharmaceutical Company through 4 years of cooperation. Screening, years of follow-up research, and verification of clinical drugs, successfully established a rhesus monkey model of spontaneous metabolic syndrome, and at the same time deeply studied the physiological, biochemical and cardiovascular ultrasound imaging characteristics of metabolic syndrome in the process of development and use The clinical drug Pioglitazone evaluated the model.
The naturally occurring metabolic syndrome rhesus monkey model constructed this time is very similar to humans in its pathogenesis, physiological and biochemical indicators and response to drugs, and its changes in cardiovascular function, especially vascular endothelial function, are also very close to humans. Metabolic syndrome is closely related to the occurrence and development of diabetes, hypertension, atherosclerosis, coronary heart disease and other cardiovascular diseases. Studies have shown that MS can increase the prevalence of heart tube diseases by 1.5-3 times and the prevalence of type 2 diabetes by 5 times. Since the rhesus monkey is closer to humans in physiological, pathological and genetic aspects than common experimental animals such as large mice, the construction of the rhesus monkey model has unique advantages for the study of the mechanism of metabolic syndrome. More importantly, it can also be used Pre-clinical evaluation of new drugs to improve the success rate of clinical trials.
At present, the molecular genetics and disease mechanism research using the rhesus monkey model of metabolic syndrome has been fully carried out. IMM will use the latest technical means to conduct in-depth research on the model, discover important disease genes, and reveal the molecules of disease development. Mechanism, and use this as a basis to find safer and more effective treatments and more sensitive diagnostic methods to make it occupy a commanding height in the international translational medicine landscape. This model has gained widespread international attention. International pharmaceutical giants such as Roche, AstraZeneca and Merck have expressed great interest in this model, and its huge value in the field of preclinical research is evident.
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